Investigating the Cancer and Aging Link

through Systems Biology (CALSYS)

Institute for Biostatistics and Informatics

in Medicine and Ageing Research, Rostock

invite you cordially to the

RoSyBA: Rostock Symposium on Systems Biology and Bioinformatics in Ageing Research

15^th-17^th September 2011

Venue: Kurhaus Warnemünde, Rostock, Germany (15^th/16^th), Institut fuer Physiologie, Rostock (17^th, transfer will be provided)

http://goethe.informatik.uni-rostock.de/ibima/rosyba2011/

The workshop is kindly sponsored by the BMBF, the SENS Foundation, Sanofi-Aventis and by the Department of

Medicine and the Department of Aging Science and Humanities (Interdisz. Fakultät), Univ. Rostock.

Registration

Registration is still possible on site. Fees: 300€ for Academia/Industry, 200€ for Graduate Student/Trainee.

Day Tickets: Thu: 50%, Fri: 70%, Sat: 30% of the fee as above.

Aims and Topics

In an “ageing society”, healthspan extension is most important. As in 2010 (Rejuvenation Res. 13:763-7), talks in this meeting demonstrate that ageing is a complex process, where in-silico work can be most useful to gain insight, and to find interventions. Specific topics of this year’s meeting are “Cancer and Ageing”, and a focus on work funded by the German ministry (BMBF).

Preliminary Program

Thursday 15.09.2011 (Kurhaus Warnemünde)

16:00-16:10 Opening

Chair: Georg Fuellen, Julio Vera

16:10-17:00 Stuart Kim, Stanford University, USA: "Genome-wide views of ageing gene networks"

17:00-17:30 Andreas Höflich, Leibniz Institute, Dummerstorf, Germany: "Interactions between growth, metabolism and aging"

17:30-17:50 Daniel Wuttke, University of Liverpool, UK: “Comparative Interactomics of DR-Essential Genes” (talk rescheduled)

Chair: Stuart Kim

18:10-18:40 Pat Langley, Arizona State University: "Computational Support for Systems Biology of Aging" (speaker changed, talk rescheduled, via Internet)

18:40-19:05 Niels Grabe, University of Heidelberg "From in vitro models to networks: approaches for studying aging skin"

19:05-19:20 Attila Altiner, University Rostock: “’Successful Ageing’ in the year 2025: Dreams and nightmares of a General Practitioner”

19:30-21:00 Welcome          

Friday 16.09.2011 (Kurhaus Warnemünde)

9:20- 9:30 Announcements

Chair: Anne Brunet

9:30-10:15 Jan Hoeijmakers, Erasmus University, Rotterdam, Netherlands: “The Genome Maintenance: Impact on Aging and Disease”

10:15-10:45 Manuel Collado, Spanish National Cancer Research Centre (CNIO), Madrid, Spain: "Impact of tumour suppressors on aging" (speaker changed)

10:45-11:05 Kristen Fortney, University of Toronto, Canada: “Mining genome-wide drug-response compendia to discover novel calorie restriction mimetics”

Chair: Günter Lepperdinger

11:30-12:15 Anne Brunet, Stanford, USA: “Neural stem cells and aging"

12:15-12:35 Ana Viñuela, King’s College London, UK: “Genome-wide transcriptome analysis with age and the effect of natural genetic variation in humans”

12:35-12:55 Aurel Popa-Wagner, University of Greifswald, Germany: “Identification of new therapeutics targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke“

12:55-13:15 Adolf E. Schindler, University of Essen, Germany: “Isoflavones and breast cancer”

Chair: Manuel Collado

14:30-15:15 Günter Lepperdinger, Institute for Biomedical Aging Research, Innsbruck, Austria: “Homeodynamic fitness - age-related dysbalance in mesenchymal stem cell

renewal and progenitor molding”

15:15-15:45 Alexandra Stolzing, Fraunhofer Inst. Cell Therapy and Immunology, Leipzig, Germany: “Into the deep: signal pathway analysis in aged MSC” (talk rescheduled)

15:45-16:05 Katrin Zeilinger, Charite, Berlin, Germany: “OXISYS - Role of oxidative injury in aging and therapeutic implications” (talk rescheduled)

16:30-16:50 Brief Business Meeting: Submission of Meeting Report, RoSyBA 2012/2013, Stem Cell Ageing

Chair: Jan Hoeijmakers

16:50-17:10 Joern Dengjel, University Hospital Freiburg, Germany: "Omics Analysis to pave the Road of Systems Biology in Kidney Aging"

17:10-17:30 Claudia Gey, University of Luebeck, Germany: "Oxygen signaling and metabolism in a cell model of oncogene-induced senescence"

17:30-17:50 Fiete Haack, University of Rostock, Germany: "The role of Lipid Rafts in Aging and Cellular Senescence"

17:50-18:10 Ulf Schmitz, University of Rostock, Germany: "Integrating Bioinformatics and Systems Biology to elucidate the role of miRNAs in cancer and aging"

18:10-18:30 Bernd Schmeck, Charite, Berlin: "Systems Biology of Inflammation in Ageing" (talk rescheduled)

19:30-21:30 Boat Trip -- registered participants (boat leaving close to the main train station and close to the ferry to "Hohe Duene", see map)

Saturday 17.09.2011 (Institut fuer Physiologie)

8:25- 9:00 Free transfer from Hotel Neptun (just opposite of Kurhaus Warnemünde) to Institut fuer Physiologie – registered participants – please inquire at registration desk – dept. 8:25 on time!

9:10- 9:15 Announcements

Chair: Thomas von Zglinicki

9:15-10:00 Joao Pedro de Magalhaes, University of Liverpool, UK: “Building haystacks and finding needles in the genomics of ageing”

10:00-10:25 Steffen Priebe, HKI, Jena: "RNA-Seq data analysis to study aging within a multi-species approach"

10:25-10:50 Stefan Schuster, Univ. Jena: "Metabolic Pathway Analysis of NAD+ metabolism with special reference to age research"

11:10-11:35 Bianca Habermann, Max Planck Institute for Biology of Ageing, Cologne: "Finding cross-links and mechanistic links in biological networks"

11:35-12:00 Axel Kowald, Humboldt University, Berlin: "Modelling the effects of SOD overexpression on ROS metabolism and protein quality control"

Chair:  Joao Pedro de Magalhaes

13:00-13:45 Thomas von Zglinicki, University of Newcastle, UK: "Mitochondrial dysfunction in cell senescence"

13:45-14:10 Jörg Galle, University of Leipzig: “Modeling the Ageing Epigenome”

14:10-14:35 Jürgen Sühnel, Leibniz Institute for Ageing Research, Jena “Data and Information Processing for Age Research”

14:55-15:20 Saleh Ibrahim / Georg Fuellen, University of Lübeck / Rostock “Mitochodrial genome and aging: a systems biology approach”

15:20-15:45 Hans Kestler, University of Ulm “Boolean networks and their evolution for modeling gene regulation”

16:05-16:10 Free transfer from Institut fuer Physiologie to main train station – registered participants – please inquire at registration desk – dept. 16:05 on time!

Organizers

Dr. Julio Vera

Systems Biology and Bioinformatics

Ulmenstrasse 69 (building 3, 3rd floor)

18057 Rostock, Germany

Room 402

+49 381 498-7681

+49 381 498-7572

http://calsys.informatik.uni-rostock.de/

Prof. Dr. Georg Fuellen

Director, Institute for Biostatistics and Informatics in Medicine and Ageing Research -- IBIMA

(formerly IMIB -- Institute for Medical Informatics and Biometry)

University of Rostock, Medical Faculty

Ernst-Heydemann-Str. 8

18057 Rostock, Germany

Phone + 49 381 494-7360

Fax + 49 381 494-7203

http://www.ibima.med.uni-rostock.de/